Traumatic brain injury (TBI) is a leading cause of injury, disability, and death in the United States
Amantadine treatment was associated with improvement of consciousness at day 5 (amantadine: 86
• Amantadine has been investigated in cognitive recovery after traumatic brain injury
It appears to be an anticholinergic (specifically at
Traumatic brain injurycyes
However, there is a paucity of studies on the effectiveness of amantadine in patients with severe stroke especially large hemisphere infarction (LHI)
Methods: We enrolled 184 patients who were in a vegetative or
7,8 Amantadine could pass the blood-brain barrier (BBB) easily and is measurable in the cerebrospinal fluid (CSF)
Improves cognition similarly to Amantadine iii
Dextroamphetamine: Sympathomimetic neurostimulator similar to Methylphenidate 7
Background: Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS)
Background: Traumatic brain injury (TBI) caused by a high-speed transportation accident results in a mechanism of injury commonly described as diffuse axonal injury (DAI), which is associated with a reduction in dopamine turnover in the brain
(Level B)
Amantadine is an established dopamine agonist that supports neurological function
Both rimantadine and, to a lesser extent Abstract Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury (TBI), the clinical use for this purpose is highly prevalent and is often based on inferred belief systems
2 µg/ml (Bode et al
SSRIs, SNRIs, antipsychotics, zolpidem and amantadine, as well as other drugs, have We retrospectively reviewed the charts of 12 subjects with brain injury who were treated with amantadine
But it's thought to work by blocking NMDA receptor in the brain, which raises dopamine levels
16,17 Several of these dopaminergic effects are seen at concentrations higher than those that are used clinically in humans
Introduction: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI)